N-arylsulfonyl-3-substituted indoles having serotonin...

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 209/14 (2006.01) A61K 31/4045 (2006.01) A61P 25/00 (2006.01) C07D 209/10 (2006.01) C07D 209/12 (2006.01) C07D 209/18 (2006.01) C07D 209/20 (2006.01) C07D 209/42 (2006.01) C07D 401/12 (2006.01) C07D 403/06 (2006.01) C07D 403/12 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2509982

The present invention relates to novel N-arylsulfonyl-3-substituted indole compounds, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their geometric forms, their N-oxides, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates and pharmaceutically acceptable compositions containing them. This invention particularly relates to novel N-arylsulfonyl-3-substituted indoles of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their pharmaceutically acceptable salts, their pharmaceutically acceptable solvates, and pharmaceutically acceptable compositions containing them. This invention also relates to the process for preparing compounds of the general formula (I), pharmaceutical compositions containing such compounds and the use of such compounds and compositions in medicine. This invention also relates to the novel intermediates involved therein and process of their preparation.

La présente invention concerne de nouveaux composés d'indoles N-arylsulfonyl-3-substitués, leurs dérivés, analogues, formes tautomères, stéréoisomères, formes géométriques, N-oxydes, polymorphes, sels pharmaceutiquement acceptables, solvates pharmaceutiquement acceptables, et des compositions pharmaceutiquement acceptables contenant ces composés. L'invention concerne en particulier de nouveaux composés d'indoles N-arylsulfonyl-3-substitués de formule générale (I), leurs dérivés, analogues, formes tautomères, stéréoisomères, polymorphes, sels pharmaceutiquement acceptables, solvates pharmaceutiquement acceptables, et des compositions pharmaceutiquement acceptables contenant ces composés. L'invention concerne en outre la méthode de préparation de composés de formule générale (I), des compositions pharmaceutiques contenant ces composés, et l'utilisation de ces composés et compositions en médecine. L'invention concerne enfin de nouveaux intermédiaires intervenant dans ces composés et compositions et leur méthode de préparation.

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