N-benzyl-3-indenylacetamide derivatives for treating neoplasia

Details N-benzyl-3-indenylacetamide derivatives for treating neoplasia N-benzyl-3-indenylacetamide derivatives for treating neoplasia

C - Chemistry, Metallurgy

07

D

C07D 213/56 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) A61K 31/50 (2006.01) A61K 31/505 (2006.01) C07D 215/14 (2006.01) C07D 237/08 (2006.01) C07D 239/26 (2006.01) C07D 241/12 (2006.01)

Patent

CA 2314339

Substituted condensation products of N-benzyl-3-indenylacetamides of formula (I) with heterocyclic aldehydes are useful for inducing or promoting apoptosis and for arresting uncontrolled neoplastic cell proliferation, and are specifically useful in the arresting and treatment of neoplasias, including precancerous and cancerous lesions.

L'invention concerne des produits de condensation substitués de N-benzyl-3-indénylacétamides de formule (I) avec des aldéhydes hétérocycliques, qui sont utiles pour provoquer ou activer l'apoptose et pour enrayer une prolifération incontrôlée de cellules néoplasiques, et spécifiquement utiles pour enrayer et traiter des néoplasies, y compris des lésions précancéreuses et cancéreuses.

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