C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/04 (2006.01) A61K 31/4245 (2006.01) A61K 31/67 (2006.01) C07C 229/14 (2006.01) C07C 229/20 (2006.01) C07C 229/22 (2006.01) C07D 333/16 (2006.01) C07D 409/04 (2006.01) C07F 9/30 (2006.01) C07F 9/38 (2006.01) C07F 9/48 (2006.01) C07F 9/59 (2006.01) C07F 9/6553 (2006.01) C07F 9/6558 (2006.01)
Patent
CA 2472713
The present invention encompasses compounds of Formula (I) as well as the pharmaceutically acceptable salts and hydrates thereof. The compounds are useful for treating immune mediated diseases and conditions, such as bone marrow, organ and tissue transplant rejection. Pharmaceutical compositions and methods of use are included.
La présente invention concerne des composés de formule (I) ainsi que leurs sels et hydrates acceptables du point de vue pharmaceutique. Lesdits composés sont utiles pour traiter les maladies et états pathologiques liés à l'immunité tels que le rejet de transplantation de moelle osseuse, d'organe ou de tissu. L'invention a également pour objet des compositions pharmaceutiques et des procédés d'utilisation.
Doherty George A.
Hale Jeffrey J.
Li Zhen
Mills Sander G.
Merck & Co. Inc.
Merck Sharp & Dohme Corp.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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