N-benzyl anthracyclines

Details N-benzyl anthracyclines N-benzyl anthracyclines

C - Chemistry, Metallurgy

07

H

260/208.1

C07H 15/24 (2006.01) C07H 15/252 (2006.01)

Patent

CA 1111028

ABSTRACT OF DISCLOSURE N-Benzyl and N,N-dibenzyl derivatives of the anthracycline compounds adriamycin and dauno- mycin, said derivatives having anti-cancer properties and being active against leukemia p-388 in mice, for example. The N,N-dibenzyl derivatives have the unique quality of exhibit- ing a loss of DNA-binding properties.

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