N-benzyl-indoles

Details N-benzyl-indoles N-benzyl-indoles

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/395 (2006.01) A61K 31/495 (2006.01) A61K 31/695 (2006.01) C07D 401/06 (2006.01) C07D 401/10 (2006.01) C07D 403/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2048096

A compound of the formula see Formula in which R1 is hydrogen, halo, C1-4 alkyl, C1-4 alkoxy, nitrile, optionally protected carboxy, optionally protected tetrazolyl, trihalomethyl, hydroxy-C1-4 alkyl, aldehydo, - CH2Z, -CH=CH-Z or -CH2CH2Z where Z is optionally protected carboxy or optionally protected tetrazolyl; R2 is halo, nitrile, an optionally protected acid group or -CONR7R8 where R7 and R8 are each hydrogen or C1-4 alkyl; R3 and R4 are each hydrogen, C1-4 alkyl, optionally substituted phenyl, or C1-4 alkyl substituted by -CONR7R8 or an optionally protected acid group; R5 is see Formulas where W is -CH=CH-, -CH=N-, -N=CH-, -O- or -S-, R9 is hydrogen, halo, C1-4 alkyl, C1-4 alkoxy or trihalomethyl, and R10 is hydrogen, C1-4 alkyl, C2-6 alkenyl, C3-6 cycloalkyl or C1-4 alkyl-C3-6 cycloalkyl; R6 is hydrogen or C1-4 alkyl; X is -O-(CH2)n CR11CR12-, -CR11R12-, -CR11R12.(CH2)n.CR13R14- or -CR11=CR12- where R11, R12, R13 and R14 are each hydrogen or C1-4 alkyl, and n is 0, 1 or 2; and Y is -O-CR15R16-, -CR15=CR16- or -CR15 R16,CR17R18- where R15, R16, R17 and R18 are each hydrogen or C1-4 alkyl; or a salt thereof. The compounds in unprotected form are active as leukotriene antagonists.

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