N-benzyl substituted pyridyl porphyrin compounds and methods...

Details N-benzyl substituted pyridyl porphyrin compounds and methods... N-benzyl substituted pyridyl porphyrin compounds and methods...

A - Human Necessities

61

K

A61K 31/555 (2006.01)

Patent

CA 2622988

The present invention relates to N-Benzyl-Substituted Pyridyl Porphyrin Compounds, compositions comprising an effective amount of an N-Benzyl- Substituted Pyridyl Porphyrin Compound and methods for treating or preventing injury due to exposure to a reactive species, erectile dysfunction, urinary incontinence, lung disease, hyperoxia, neurodegenerative disease, liver disease, myocardial damage during cardioplegia, an inflammatory condition, a reperfusion injury, an ischemic condition, a cardiovascular disease, diabetes, a diabetic complication, cancer, a side effect of cancer chemotherapy, or a radiation- induced injury, and methods for prolonging the half-life of an oxidation-prone compound, comprising administering to a subject in need thereof an effective amount of an N-Benzyl- Substituted Pyridyl Porphyrin Compound.

L'invention porte sur des composés de pyridyle porphyrine à substitution N-benzyle, sur des compositions comprenant une quantité effective d'un composé pyridyle porphyrine à substitution N-benzyle et sur des méthodes de traitement ou de prévention de lésions provoquées par l'exposition à une espèce réactive, de la dysérection, l'incontinence urinaire, les maladies pulmonaires, l'hyperoxie, les maladies neurodégénératives, les troubles hépatiques, une lésion myocardique apparue au cours d'une cardioplégie, un état inflammatoire, une lésion de reperfusion, un état ischémique, les maladies cardio-vasculaires, le diabète, les complications diabétiques, le cancer, un effet secondaire d'une chimiothérapie ou une lésion induite par des rayonnements. L'invention porte également sur des méthodes visant à prolonger la durée de vie d'un composé enclin à l'oxydation, ces méthodes consistant à administrer à un sujet nécessitant ce type de traitement une quantité effective d'un composé pyridyle porphyrine à substitution N-benzyle.

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