N-benzylbispyridine compounds

Details N-benzylbispyridine compounds N-benzylbispyridine compounds

C - Chemistry, Metallurgy

07

D

260/273

C07D 471/08 (2006.01)

Patent

CA 1105023

ABSTRACT OF THE DISCLOSURE This invention relates to bispidine derivatives of the formula Image where R1 is H or C6H5, R2 is H, Cl or CF3, R3 is H, F or Cl and X is 0 or 1, with the proviso that R1, R2 and R3 cannot all be H when X is 0. The compounds are prepared by condensing N-monobenzylbispidine with appropriately substituted phenylethyl halides or by a Mannich reaction of N-benzyl-piperid-4-one with appropriately substituted phenylalkylamines, followed by redustion. They exhibit mainly anto-arrhythmic action.

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