N.beta.-substituted 8-.beta.-aminoethylergolin-1...

Details N.beta.-substituted 8-.beta.-aminoethylergolin-1... N.beta.-substituted 8-.beta.-aminoethylergolin-1...

C - Chemistry, Metallurgy

07

D

260/206.7

C07D 457/02 (2006.01)

Patent

CA 1050532

ABSTRACT OF THE DISCLOSURE: The invention proposes new N.beta.-substituted derivatives of 8-.beta.- aminoethylergolin-I of the general formula I Image (I) wherein R1 designates a straight or a branched alkyl with 1 to 8 carbon atoms, a phenylalkyl the alkyl of which contains 1 to 4 car- bon atoms and the phenyl moiety of which can be mono-, di or tri- substituted with chlorine, bromine, a hydroxy group or an alkoxy group with 1 to 4 carbon atoms, R2 designates a hydrogen atom or an alkyl group with 1 to 4 carbon atoms, and R3 designates a hydro- gen atom or a methyl group, as well as pharmaceutically suitable addition salts therof with inorganic or organic acids, and methods of preparing the same. These compounds exhibit, in particular, a remarkable prolactin-inhibitory effect.

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