N-¢5-¢¢¢5-alkyl-2-oxazolyl!methyl!thio!-2-thiazolyl!...

Details N-¢5-¢¢¢5-alkyl-2-oxazolyl!methyl!thio!-2-thiazolyl!... N-¢5-¢¢¢5-alkyl-2-oxazolyl!methyl!thio!-2-thiazolyl!...

C - Chemistry, Metallurgy

07

D

C07D 417/12 (2006.01) A61K 31/427 (2006.01) A61K 31/454 (2006.01) A61P 35/00 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2417254

The present invention describes compounds of the formula: and enantiomers, diasteromers, solvates, and pharmaceutically acceptable salts thereof. The formula compounds are protein kinase inhibitors and are useful in the treatment of proliferative diseases, for example, cancer, inflammation and arthritis. They may also be useful in the treatment of Alzheimer's disease, chemotherapy-induced alopecia, and cardiovascular disease.

Cette invention a trait à des composés correspondant à la formule (I), à leurs énantiomères, leurs diastéromères, leurs solvates et leurs sels acceptables du point de vue pharmaceutique. Les composés selon cette formule, qui sont des inhibiteurs de la protéine kinase, se révèlent des plus utiles dans le traitement de maladies prolifératives, notamment du cancer, des maladies inflammatoires et de l'arthrite. Ils sont également des plus utiles pour traiter la maladie d'Alzheimer, l'alopécie provoquée par une chimiothérapie et les maladies cardio-vasculaires.

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