A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01)
Patent
CA 2646597
The present invention provides methods of diagnosis, providing a prognosis and a therapeutic target for the treatment of cancers that overexpress N-cadherin and Ly6-E, including prostrate and bladder cancers. The invention further provides methods of drug discovery to identify pharmaceutical agents that inhibit or prevent the binding of N-cadherin and Ly6-E to its receptor, which are useful when used alone or in combination with known chemotherapeutics, immunotherapeutics, and radiotherapy for the reversal of resistance, tumor progression, and metastasis of cancers associated with the overexpession of N-cadherin and Ly6-E.
La présente invention concerne une méthode de diagnostic, une méthode d'établissement de pronostic et une cible thérapeutique servant au traitement de cancers qui surexpriment les gènes N-cadhérine et Ly6-E, tels que les cancers de la prostate et de la vessie. Cette invention concerne également des méthodes de découverte de médicaments permettant d'identifier des agents pharmaceutiques qui inhibent ou empêchent la liaison des gènes N-cadhérine et Ly6-E à leur récepteur et qui permettent, utilisés seuls ou conjointement à une chimiothérapie, immunothérapie ou radiothérapie connue, d'inverser la résistance, l'évolution tumorale et la métastase de cancers associés à la surexpression des gènes N-cadhérine et Ly6-E.
Fetherstonhaugh & Co.
The Regents Of The University Of California
LandOfFree
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