N-carbamoylmethyl-4-(r)-phenyl-2-pyrrolidinone, method of...

Details N-carbamoylmethyl-4-(r)-phenyl-2-pyrrolidinone, method of... N-carbamoylmethyl-4-(r)-phenyl-2-pyrrolidinone, method of...

C - Chemistry, Metallurgy

07

D

C07D 207/26 (2006.01) A61K 31/4015 (2006.01) A61P 21/02 (2006.01) A61P 25/00 (2006.01) A61P 25/24 (2006.01)

Patent

CA 2647206

The invention relates to the R-enantiomer of N-carbamoylmethyl-4-phenyl-2-pyrrolidinone (R- Carphedon) of pharmacological value. The method of its preparation includes the N-alkylation of 4(R)-phenyl-2-pyrrolidinone with ethyl bromoacetate in the presence of a strong base and the treatment of intermediate N-ethoxycarbonylmethyl-4(R)-phenyl-2-pyrrolidinone with ammonia.

Cette invention concerne le R-énantiomère de N-carbamoylmethyl-4(r)-phenyl-2-pyrrolidinone (R- Carphédon) ayant une valeur pharmacologique. Le procédé consistant à le préparer comprend la N-alkylation de 4(R)-phenyl-2-pyrrolidinone avec du bromoacétate d'éthyle en présence d'une base solide, et le traitement du produit intermédiaire N-ethoxycarbonylmethyl-4(R)-phenyl-2-pyrrolidinone avec de l'ammoniac.

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