C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 223/16 (2006.01) A61K 31/55 (2006.01) A61P 7/00 (2006.01) A61P 11/00 (2006.01) A61P 35/00 (2006.01) C07D 403/12 (2006.01) C07K 5/02 (2006.01) C07K 5/06 (2006.01) C07K 5/078 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2358955
The present invention provides a method of inhibiting matrix metallo- proteinases (MMPs) in a patient in need thereof comprising administering to the patient an effective matrix metalloproteinase inhibiting amount of the N- carboxymethyl substituted benzolactams of formula (1) wherein A is -OH or - NRR'. Such inhibitors are useful in treating neoplasms, atherosclorosis, and chronic inflammatory diseases. The present invention also provides novel N- carboxymethyl substituted benzolactams of formula (1a) wherein A is -NRR'.
L'invention porte sur un procédé d'inhibition chez un patient le nécessitant des métallo-protéinases (MMPs) consistant à lui administrer une dose inhibitrice efficace de benzolactames à substitution N-carboxyméthyle de formule (1) dans laquelle A est -OH ou -NRR'. Ces inhibiteurs s'utilisent pour traiter les néoplasmes, l'athérosclérose, et les troubles inflammatoires chroniques. L'invention porte également sur de nouveaux benzolactames à substitution N-carboxyméthyle de formule (1a) dans laquelle A est -NRR'.
Flynn Gary A.
Janusz Michael J.
Warshawsky Alan
Aventis Pharmaceuticals Inc.
Bereskin & Parr
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