A - Human Necessities – 01 – N
Patent
A - Human Necessities
01
N
A01N 59/00 (2006.01) A01N 37/32 (2006.01) A01N 41/06 (2006.01) A01N 43/50 (2006.01) A01N 43/90 (2006.01) A01N 59/02 (2006.01)
Patent
CA 2375976
The antimicrobial efficacy of N-chlorosulfamate solutions, namely buffered aqueous combinations of HClNSO3-(mono-N-chlorosulfamate) and Cl12NSO3 (di-N-chlorosulfamate), herein referred to as "stabilized hypochlorite", can be markedly enhanced by the addition of certain organic dopants. The dopants themselves are select hypochlorite stabilizing agents, which are known to readily form stable organochloramides when reacted with "free" hypochlorite (HOCl or NaOCl). Highly effective antimicrobial enhancing dopants include 5,5-dialkyl hydantoins, arylsulfonamides, and succinimides. Examples of these include 5,5-dimethylhydantoin, benzenesulfonamide, and succinimide. Other, less effective dopants include glycolurils. Generally, the dopant is present in a minor mole fraction, relative to the molar amount of stabilized hypochlorite present in the enhanced antimicrobial solution.
Selon cette invention, on peut améliorer considérablement l'efficacité antimicrobienne des solutions de N-chlorosulfamate, notamment des solutions aqueuses à tampon de HClNSO3-(mono-N-chlorosulfamate) et de Cl2NSO3 (di-N-chlorosulfamate), ci-après "hypochlorite stabilisé", grâce à l'ajout de certains dopants organiques. Ces dopants se présentent comme des agents sélectionnés stabilisant l'hypochlorite qui sont connus pour pouvoir facilement former des organochloramides stables lors d'une réaction avec un hypochlorite "libre" (HOCl ou NaOCl). Les dopants efficaces des propriétés antimicrobiennes comprennent des 5,5-dialkyle hydantoines, des arylsulfonamides et des succinimides; on citera parmi ceux-ci 5,5-diméthylhydantoine, sulfonamide de benzène et succinimide. D'autres dopants, moins effectifs, comprennent des glycoluriles. En règle générale, le dopant est présent dans une fraction molaire mineure par rapport aux quantités molaires de l'hypochlorite stabilisé présent dans la solution antimicrobienne améliorée.
Hilgers Debra S.
Rees Wayne M.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
S.c. Johnson & Son Inc.
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