N-cyano-n'-pyridylguanidines as serotonin antagonists

Details N-cyano-n'-pyridylguanidines as serotonin antagonists N-cyano-n'-pyridylguanidines as serotonin antagonists

C - Chemistry, Metallurgy

07

D

C07D 213/75 (2006.01) A61K 31/44 (2006.01) C07D 213/84 (2006.01) C07D 213/89 (2006.01)

Patent

CA 2143756

Novel compounds of the Formula I below are provided Image In these compounds, or their tautomeric forms, the attachment to the pyridine ring is in the 3- or 4-position. R' and R" are the same or different and stand for hydrogen, halogen, or trifluoromethyl, hydroxy, C1-C4 alkyl, C1-C4alkoxy, nitro, or cyano groups. Alkylene stands for a straight C1-C8 carbon chain which is substituted by at least one hydroxy, halogen, nitro or cyano group, a branched C1-C8; carbon chain, or a branched C1-C8 carbon chain, which is substituted by hydroxy, halogen, nitro or cyano groups. X stands for oxygen, for -S(O)n-, where n stands for an integer from 0 to 2, or for -N-R1 where R1 is hydrogen or C1-C4 alkyl. R stands for hydrogen or for at least one C1-C4 alkyl or C1-C4 alkoxy, hydroxy, halogen, trifluoromethyl, cyano, carboxamido, sulphanoyl or nitro radicals. Their N-oxides and their pharmaceutically-acceptable, non- toxic salts are also provided.

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