N-cyclic sulfonamido inhibitors of gamma secretase

Details N-cyclic sulfonamido inhibitors of gamma secretase N-cyclic sulfonamido inhibitors of gamma secretase

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/4406 (2006.01) A61P 25/28 (2006.01) C07D 209/42 (2006.01) C07D 215/58 (2006.01) C07D 217/22 (2006.01) C07D 235/02 (2006.01) C07D 241/50 (2006.01) C07D 243/14 (2006.01) C07D 263/56 (2006.01) C07D 273/00 (2006.01) C07D 277/06 (2006.01) C07D 405/06 (2006.01) C07D 471/04 (2006.01) C07D 491/10 (2006.01)

Patent

CA 2567343

The invention provides N-cyclic sulfonamido compounds for use in treating or preventing cognitive disorders, such as Alzheimer~s Disease. Compounds of particular interest are defined by Formula (I), wherein R4, R5, R6, R7 and R8 are as described in the specification. The invention also encompasses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of treating cognitive disorders, including Alzheimer~s disease using compounds of Formula (I).

L'invention concerne des composés sulfonamido N-cycliques qui s'utilisent dans le traitement ou la prévention des troubles cognitifs, tels que la maladie d'Alzheimer. Des composés revêtant un intérêt particulier sont représentés par la formule (I), dans laquelle R4, R5, R6, R7 et R8 sont tels que décrits dans le descriptif. Par ailleurs, l'invention concerne des compositions pharmaceutiques qui contiennent les composés représentés par la formule (I), ainsi que des méthodes de traitement des troubles cognitifs, y compris la maladie d'Alzheimer, au moyen des composés de la formule (I).

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