N-cycloalkylalkylamines, their process of preparation, their...

Details N-cycloalkylalkylamines, their process of preparation, their... N-cycloalkylalkylamines, their process of preparation, their...

C - Chemistry, Metallurgy

07

D

167/207, 167/276

C07D 333/20 (2006.01) A61K 31/135 (2006.01) A61K 31/33 (2006.01) C07C 211/26 (2006.01) C07D 307/52 (2006.01) C07D 409/06 (2006.01)

Patent

CA 2037114

A compound which is a N-cycloalkylalkylamine of general formula (I): (see Formula I) in which: R1 is a furyl radical or a thienyl radical, or, with the proviso that Q represents a cyclopropane-1,2-diyl group (see Formula II) R1 is a phenyl radical, R2 is lower alkyl, R3 is hydrogen or lower alkyl, m has a value of 1 or 2, R4 is cycloalkyl -CH(CH2)n, in which n has values from 2 to 5, R5 is phenyl which can be monosubstituted, disubstituted or trisubstituted by halogens or by identical or different lower alkyl or alkoxy radicals, and R5 is thienyl, Q represents an ethylene-1,2-diyl group (-CH=CH-) or a cyclopropane-1,2-diyl group (see Formula III), and their salts additions with pharmaceutically acceptable acids. A pharmaceutical composition comprising a compound of general formula (I) with the above definitions for the treatment of disturbances of a neurological type and/or psychic type, the dysfunctions of the gastro-intestinal tract, and/or gastric- duodenal ulcerations.

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