N-formyl hydroxylamine compounds as inhibitors of pdf

Details N-formyl hydroxylamine compounds as inhibitors of pdf N-formyl hydroxylamine compounds as inhibitors of pdf

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/4402 (2006.01) A61P 31/04 (2006.01) C07D 207/16 (2006.01) C07D 405/12 (2006.01) H03B 5/18 (2006.01)

Patent

CA 2448526

n-[01-oxo-2-alkyl-3-(N-hydroxyformamido)-propyl]-(carbonylamino-aryl or heteroaryl)- azacyclo 4-7 alkanes or thiazacyclo 4-7 alkanes or imidazacyclo 4- 7 alkanes have interesting properties, e.g. in the treatment or prevention of disorders amenable to treatment by peptidyl deformylase inhibitors such as treatment of bacterial infections.

La présente invention concerne le N-[1-oxo-2-alkyl-3-(N-hydroxyformamido)-propyl]-(carbonylamino-aryl ou hétéroaryl)-azacyclo ¿4-7? alcanes ou thiazacyclo ¿4-7? alcanes ou imidazacyclo ¿4-7 ?alcanes¿ ?présentant des propriétés intéressantes, par exemple dans le traitement ou la prévention de troubles susceptibles d'être traités par des inhibiteurs de la peptidyle déformylase tel que le traitement d'infections bactériennes.

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