N-formyl peptide receptor complex with a g-protein kinase...

Details N-formyl peptide receptor complex with a g-protein kinase... N-formyl peptide receptor complex with a g-protein kinase...

C - Chemistry, Metallurgy

07

K

C07K 14/00 (2006.01) A61K 38/05 (2006.01) A61K 38/07 (2006.01) C07K 5/083 (2006.01) C07K 5/103 (2006.01) C07K 14/72 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2387559

A method of inhibiting a pro-inflammatory response of a human peripheral blood mononuclear cell or polymorphonuclear cell, or fixed tissue cell is described. The cell is contacted with a pro-inflammatory agent to stimulate a pro- inflammatory response. Then, the cell is contacted with a G protein kinase signal pathway modification agent, thereby inhibiting inflammatory response signal transduction pathways mediated by G protein. A receptor complex is described wherein a G protein kinase signal pathway modification agent binds to a cell surface receptor of a human peripheral blood mononuclear cell or polymorphonuclear cell that has been stimulated by a pro-inflammatory agent.

L'invention concerne un procédé d'inhibition d'une réponse pro-inflammatoire d'une cellule sanguine périphérique, humaine, mononucléaire ou polymorphonucléaire, ou d'une cellule tissulaire fixe. Ce procédé consiste à mettre en contact la cellule avec un agent pro-inflammatoire, afin de stimuler une réponse pro-inflammatoire, puis à mettre la cellule en contact avec un agent de modification du mécanisme de signalisation de la protéine kinase G, de manière à inhiber les mécanismes de transduction du signal de réponse inflammatoire, induits par la protéine G. L'invention concerne un complexe de récepteurs, dans lequel un agent de modification du mécanisme de signalisation de la protéine G kinase se lie à un récepteur de surface cellulaire d'une cellule sanguine périphérique humaine, mononucléaire ou polymorphonucléaire, qui a été stimulée par un agent pro-inflammatoire.

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