N-heteroaryl-4-quinolinamines, a process for their...

Details N-heteroaryl-4-quinolinamines, a process for their... N-heteroaryl-4-quinolinamines, a process for their...

C - Chemistry, Metallurgy

07

D

167/211, 260/277

C07D 401/12 (2006.01) A61K 31/395 (2006.01) C07D 401/14 (2006.01)

Patent

CA 2016214

- 1 - HOE 89/S 005 ABSTRACT There are described compounds OF the formula Image (I) where -R is Image , Image or Image , -R3 and R4 being independently H, loweralkyl, -CHO, -CH=CH2, -CH=CH-loweralkyl, -CH=CHCO2C2H5, -CH2N(C2H5)2 or - CH2 -N Image ; -R1 when existent is -H, loweralkyl, CH2C3CH,, -2- - CH2C=CCH2 - Image or -CH C=CCH2 Image - R5, R5 being methyl or phenyl optionally mono-substituted with loweralkyl or loweralkoxy; -R2 when existent is loweralkyl or -CH2C-CH; -X is -H, loweralkyl, loweralkoxy, halogen or trifluoromethyl; and the two -Y groups when existent are both -H, or combine to constitute -(CH2) 4-; which compounds are useful as analgesic agents, and for treating various memory dysfunctions characterized by decreased cholinergic function such as Alzheimer's disease.

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