N-heteroaryl-pyridinesulfonamide derivatives and their use...

Details N-heteroaryl-pyridinesulfonamide derivatives and their use... N-heteroaryl-pyridinesulfonamide derivatives and their use...

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/495 (2006.01) A61K 31/53 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2219742

The invention concerns pharmaceutically useful compounds of formula (Ia), in which B1, m, Ar, R y and R1 have any of the meanings defined herein, and their pharmaceutically acceptable salts, and pharmaceutical compositions containing them. The novel compounds possess endothelin receptor antagonist activity and are useful, for example, in the treatment of diseases or medical conditions in which elevated or abnormal levels of endothelin play a significant causative role. The invention further concerns processes for the manufacture of the novel compounds and the use of the compounds in medical treatment.

L'invention concerne des composés pouvant être utilisés pharmaceutiquement, présentant la formule (I), dans laquelle A<1>, A<2>, A<3>, A<4>, B<1>, m, Ar, W, X, Y, Z et R<1> correspondent à l'une des définitions données ici, leurs sels pharmaceutiquement acceptables et les compositions pharmaceutiques les contenant. Les nouveaux composés possèdent une activité d'antagonistes du récepteur de l'endothéline et sont utiles, par exemple, pour traiter des maladies ou des états médicaux dans lesquels des taux élevés ou des taux anormaux d'endothéline jouent un rôle significatif. L'invention traite, en outre, de procédés pour la fabrication des nouveaux composés et l'utilisation de ces composés dans un traitement médical.

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