N-(heterobicycloalkanes)-subtituted indoles- or...

C - Chemistry – Metallurgy – 07 – D

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C07D 451/02 (2006.01) A61K 31/46 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2531749

Use of a compound of general formula (I) for manufacturing a medicament to provide agonists or antagonists of CCR-3, or pharmaceutically acceptable salts thereof, in particular compounds of formula (I), wherein R1, R5, R6, A, B, X, W, Z, i, j, k, l and m are defined as in the description and claims. It is another object of the present invention to provide pharmaceutical compositions comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one of the compounds of the present invention or a pharmaceutically acceptable salt thereof.

L'invention concerne l'utilisation d'un composé de formule générale (1) pour fabriquer un médicament pour fournir des agonistes ou des antagonistes de CCR-3, ou des sels pharmaceutiquement acceptables de ceux-ci, en particulier des composés de formule (1), dans laquelle R?1¿, R?5¿, R?6¿, A, B, X, W, Z, i, j, k, l et m sont tels que définis dans la description et les revendications. L'invention concerne également des compositions pharmaceutiques comprenant un support pharmaceutiquement acceptable et une quantité thérapeutique efficace d'au moins un des composés selon l'invention ou d'un sel pharmaceutiquement acceptable de ceux-ci.

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