C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/42 (2006.01) A61K 31/505 (2006.01) C07D 213/85 (2006.01) C07D 239/48 (2006.01) C07D 239/50 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01)
Patent
CA 2451128
N-heterocyclic compounds that block cytokine production via inhibition of p38 kinase are disclosed. In one embodiment, compounds of the present invention are represented by Formula (I). Methods of production, pharmaceutical compositions and methods of treating conditions associated with inappropriate p38 kinase activity or TNF-.alpha. expression utilizing compounds of the present invention are also disclosed.
L'invention concerne des composés N-hétérocycliques qui bloquent la production de cytokine par l'intermédiaire de l'inhibition de la kinase p38. Dans un mode de réalisation, des composés de cette invention sont représentés par la formule (I). Ladite invention a également trait à des méthodes d'élaboration de compositions pharmaceutiques et à des méthodes de traitement de troubles liés à l'activité inadéquate de la kinase p38 ou à l'expression TNF-.alpha., au moyen des composés susmentionnés.
Ahmed Gulzar
Diller David J.
Henderson Ian
Leftheris Katerina
Metzger Axel
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
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