N-hydrocarbyl-4-substituted piperidines, their preparation...

Details N-hydrocarbyl-4-substituted piperidines, their preparation... N-hydrocarbyl-4-substituted piperidines, their preparation...

C - Chemistry, Metallurgy

07

D

C07D 211/18 (2006.01) A61K 31/435 (2006.01) C07D 211/14 (2006.01) C07D 211/22 (2006.01) C07D 211/46 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2088491

2088491 9202502 PCTABS00010 Compounds of structure (I) in which R is C1-8alkyl(phenyl)p, C2-8alkenyl(phenyl)p, C2-8alkenyl(phenyl)p, C3-8cycloalkyl or C1-8alkylC3-8cycloalkyl; p is 0 to 2; n is 0 to 6; A is a bond, oxygen, sulphur or NR1; R1 is hydrogen, C1-8alkyl or phenylC1-4alkyl; m is 0 to 3; and Ar is aryl or heteroaryl, each of which may be optionally substituted, and salts thereof; processes for preparing said compounds, pharmaceutical compositions containing them and their use in therapy, in particular as calcium blocking agents.

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