N-hydroxy-1,2-dihydro-2-oxo- 5(pyridinyl)nicotinimidamides,...

Details N-hydroxy-1,2-dihydro-2-oxo- 5(pyridinyl)nicotinimidamides,... N-hydroxy-1,2-dihydro-2-oxo- 5(pyridinyl)nicotinimidamides,...

C - Chemistry, Metallurgy

07

D

260/279.4

C07D 401/04 (2006.01) C07D 213/78 (2006.01)

Patent

CA 1175838

D.N. 3679 ABSTRACT OF THE DISCLOSURE N-Hydroxy-1-R1-1,2-dihydro-2-oxo-5-PY-6-R-nico- tinimidamides or pharmaceutically-acceptable acid-addition salts thereof, useful as cardiotonic agents, are prepared by reacting 1-R1-1,2-dihydro-2-oxo-5-PY-6-R-nicotinonitriles with hydroxylamine and are converted by reaction with polyphosphoric acid to the corresponding cardiotonically useful 1-R1-3-amino-5-PY-6-R-2(1H)-pyridinones, where R1 is hydrogen, lower-alkyl and lower-hydroxyalkyl, R is hydrogen or lower-alkyl, and PY is 4- or 3-pyridinyl or 4- or 3- pyridinyl having one or two lower-alkyl substituents.

390670

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