N-hydroxy-dibenz¢b,e!oxepin -alkylamines and -alkanoic acid...

Details N-hydroxy-dibenz¢b,e!oxepin -alkylamines and -alkanoic acid... N-hydroxy-dibenz¢b,e!oxepin -alkylamines and -alkanoic acid...

C - Chemistry, Metallurgy

07

D

167/242, 167/243

C07D 313/12 (2006.01) A61K 31/335 (2006.01) A61K 31/38 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2023951

This invention relates to N-hydroxy-dibenz[b,e]oxepinalkylamines, N-hydroxy-dibenz[b,e]oxepinalkanoic acid amides and related heterocyclic analogues of the formula (see formula I) where X together with the carbon atoms to which it is attached forms a benzene or thiophene ring; W and Z are independently hydrogen, halogen, loweralkyl, or trifluoromethyl, R1 is hydrogen, loweralkyl, or acyl; R2 is hydrogen, loweralkyl, cycloalkyl, arylloweralkyl or acyl; m is 0 or 1 and n is an integer of 0 to 12 and the pharmaceutically acceptable salty thereof. The compounds of this invention exhibit dermatological and analgesic activity.

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