A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/18 (2006.01) A61P 9/04 (2006.01) C07C 311/48 (2006.01) C07C 317/14 (2006.01) C07C 323/67 (2006.01) C07D 207/36 (2006.01) C07D 213/71 (2006.01) C07D 213/74 (2006.01) C07D 215/28 (2006.01) C07D 215/36 (2006.01) C07D 231/18 (2006.01) C07D 233/84 (2006.01) C07D 239/38 (2006.01) C07D 241/18 (2006.01) C07D 249/12 (2006.01)
Patent
CA 2645988
The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxysulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxysulfonamide derivatives.
L'invention concerne de nouveaux dérivés de N-hydroxysulfonamide fournissant du nitroxyle (HNO) en conditions physiologiques et étant utiles pour le traitement et/ou la prévention de l'apparition et/ou du développement de maladies ou de troubles répondant à une thérapie au nitroxyle, y compris la défaillance cardiaque et l'ischémie/lésions de reperfusion. Les nouveaux dérivés de N-hydroxysulfonamide libèrent NHO à une vitesse modulable dans des conditions physiologiques, la vitesse de libération de HNO étant modulée en variant la nature et l'emplacement des groupements fonctionnels sur les dérivés de N-hydroxysulfonamide.
Brookfield Frederick Arthur
Cohen Andrew D.
Courtney Stephen Martin
Frost Lisa Marie
Kalish Vincent Jacob
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Cardioxyl Pharmaceuticals Inc.
Johns Hopkins University School Of Medicine
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