C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 311/48 (2006.01) A61K 31/18 (2006.01) A61K 31/192 (2006.01) A61K 31/235 (2006.01) A61K 31/5377 (2006.01) A61P 9/04 (2006.01) A61P 9/10 (2006.01) C07D 295/192 (2006.01) C07D 333/34 (2006.01) C07D 333/38 (2006.01)
Patent
CA 2699567
The invention relates to N-hydroxylsulfonamide derivatives for formula (I), (II) or (III), in which the variables are as defined in the claims, that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. N-hydroxylsulfonamide derivatives release HNO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of the functional groups on the N-hydroxylsulfonamide derivatives.
L'invention concerne des dérivés de N-hydroxylsulfonamide de formule (I), (II) ou (III), dans lesquelles les variables sont telles que définies dans les revendications, qui donnent du nitroxyle (HNO) dans les conditions physiologiques et peuvent être utilisés dans le cadre du traitement et/ou de la prévention de la survenue et/ou de l'évolution de maladies ou d'affections réagissant à un traitement par le nitroxyle, dont l'insuffisance cardiaque et les lésions ischémiques/de reperfusion. Les dérivés de N-hydroxylsulfonamide libèrent du HNO à vitesse contrôlée dans les conditions physiologiques et la vitesse de libération du HNO peut être modulée par des modifications de la nature et de l'emplacement des groupes fonctionnels présents sur les dérivés de N-hydroxylsulfonamide.
Brookfield Frederick Arthur
Cohen Andrew D.
Courtney Stephen Martin
Frost Lisa Marie
Kalish Vincent Jacob
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Cardioxyl Pharmaceuticals Inc.
Johns Hopkins University
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