C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/04 (2006.01) A61K 31/44 (2006.01) C07D 401/06 (2006.01)
Patent
CA 2276042
N-Hydroxyurea derivatives represented by general formula (I), pharmacologically acceptable salts thereof or hydrates or solvates of the same, each having antiallergic or anti-inflammatory effects, wherein one of R1, R3 and R4 represents A while one of the remainders of R1, R3 and R4 and R2 represents 3-pyridyl or 3-pyridylalkyl, and the remainders of R1, R2, R3 and R4 independently represent each H, halogeno or optionally substituted C1-8 alkyl; R5 represents H or lower alkyl; R6 represents H, lower alkyl, C3-7 cycloalkyl or phenyl optionally substituted by halogeno, lower alkyl or lower alkoxy; and B represents a bond, C1-20 alkylene, C2-8 alkenylene or C2-8 alkynylene, or B-C(R5) represents C2-6 alkylene having an intermediate benzene ring.
Dérivés de N-hydroxyurée de formule générale (I), et leurs sels pharmaceutiquement acceptables ou leurs hydrates ou solvates, ayant des propriétés antiallergiques ou anti-inflammatoires. Dans ladite formule, l'un parmi R¿1?, R¿3? et R¿4? est A, tandis que l'un parmi R¿1?, R¿3? et R¿4? restants et R¿2? est 3-pyridyle ou 3-pyridylalkyle, et les R¿1?, R¿2?, R¿3? et R¿4? restants sont indépendamment chacun H, halogéno ou alkyle C¿1-8? éventuelllement substitué; R¿5? est H ou alkyle inférieur; R¿6? est H, alkyle inférieur, cycloalkyle C¿3-7? ou phényle éventuellement substitué par halogéno, alkyle inférieur ou alcoxy inférieur; et B est une liaison, alkylène C¿1-20?, alkénylène C¿2-8? ou alkynylène C¿2-8?, ou bien B-C (R¿5?) est alkylène C¿2-6? avec un noyau de benzène intermédiaire.
Kawahara Yoshikazu
Komatsu Toshiya
Takano Michika
Borden Ladner Gervais Llp
Nikken Chemicals Co. Ltd.
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