C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/305
C07D 405/04 (2006.01) A61K 31/415 (2006.01) C07D 233/54 (2006.01)
Patent
CA 1163999
ABSTRACT OF THE DISCLOSURE The invention relates to novel compounds of general formula I Image (I) wherein R is Cl-C6 alkyl; n is 0, 1, 2 or 3 one of R1 and R2 is hydroxy and the other is hydrogen or Cl-C6 alkyl, or R1 and R2, taken together, form an oxo group; each of Xl, X2, X3 and X4, which may be the same or different, is hydrogen; halogen; hydroxy; -NO2; -CN; Cl-C6 alkyl; Cl-C6 alkoxy; trihalo- Cl-C6 alkyl; -SR' or -COOR', R' being hydrogen or Cl-C6 alkyl; Image or Image each of R" and R"', which may be the same or different, being hydrogen or Cl-C6 alkyl; or one of Xl, X2, X3 and X4 is phenyl, phenylthio, phenoxy or benzyl, the phenyl, phenylthio. phenoxy and benzyl groups being unsubstituted or substituted by halogen, Cl-C6 alkyl, Cl 6 alkoxy, or -SR', wherein R' is as defined above, and the others are as defined above; or any two adjacent Xl, X2 X3 and X4 groups taken together, complete a saturated or unsaturated 6-membered carbocyclic ring fused to the benzene ring shown in formula (I), the carbocyclic ring being unsubstituted or substituted by one or more groups selected from halogen, Cl-C6 alkyl, Cl 6 haloalkyl, Cl-C6 alkoxy or -SR', wherein R' is as defined above, and any groups Xl to X4 not participating in the completion of such a fused ring are as defined above, and the pharmaceutically acceptable salts thereof. The compounds display elevated lipid lowering and antiatherosclerotic activity.
372135
Bergamaschi Maria
Cozzi Paolo
Lovisolo Pier P.
Mongelli Nicola
Pillan Antonio
Farmitalia Carlo Erba S.p.a.
Fetherstonhaugh & Co.
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