N-imidazolyl derivatives of 1-chroman and process for their...

C - Chemistry – Metallurgy – 07 – D

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C07D 405/04 (2006.01) A61K 31/415 (2006.01) C07D 233/54 (2006.01)

Patent

CA 1163999

ABSTRACT OF THE DISCLOSURE The invention relates to novel compounds of general formula I Image (I) wherein R is Cl-C6 alkyl; n is 0, 1, 2 or 3 one of R1 and R2 is hydroxy and the other is hydrogen or Cl-C6 alkyl, or R1 and R2, taken together, form an oxo group; each of Xl, X2, X3 and X4, which may be the same or different, is hydrogen; halogen; hydroxy; -NO2; -CN; Cl-C6 alkyl; Cl-C6 alkoxy; trihalo- Cl-C6 alkyl; -SR' or -COOR', R' being hydrogen or Cl-C6 alkyl; Image or Image each of R" and R"', which may be the same or different, being hydrogen or Cl-C6 alkyl; or one of Xl, X2, X3 and X4 is phenyl, phenylthio, phenoxy or benzyl, the phenyl, phenylthio. phenoxy and benzyl groups being unsubstituted or substituted by halogen, Cl-C6 alkyl, Cl 6 alkoxy, or -SR', wherein R' is as defined above, and the others are as defined above; or any two adjacent Xl, X2 X3 and X4 groups taken together, complete a saturated or unsaturated 6-membered carbocyclic ring fused to the benzene ring shown in formula (I), the carbocyclic ring being unsubstituted or substituted by one or more groups selected from halogen, Cl-C6 alkyl, Cl 6 haloalkyl, Cl-C6 alkoxy or -SR', wherein R' is as defined above, and any groups Xl to X4 not participating in the completion of such a fused ring are as defined above, and the pharmaceutically acceptable salts thereof. The compounds display elevated lipid lowering and antiatherosclerotic activity.

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