N-imidazolyl derivatives of substituted indole

Details N-imidazolyl derivatives of substituted indole N-imidazolyl derivatives of substituted indole

C - Chemistry, Metallurgy

07

D

C07D 403/10 (2006.01) A61K 31/415 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2066938

ABSTRACT The invention provides N-imidazolyl derivatives of substi- tuted indole of general formula (I) Image (I) wherein p is an integer of 1 to 4; A is a straight or branched C1-C4 alkylene chain; B is a direct linkage, a straight or branched, unsaturated or saturated C1-C4 hydrocarbon chain; Q is a straight or branched, saturated or unsaturated C1-C9 hydrocarbon chain, or said chain is interrupted by an oxygen atom; each of R1 and R2 independently is hydrogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkylthio, C1-C4 alkylsulfonyl, halogen or trihalomethyl; each of R3 and R5, independently, is hydrogen or C1-C4 alkyl; R4 is a -OR6 or -N(R6R7) group, wherein each of R6 and R7 independently is hydrogen, C1-C4 alkyl, phenyl or benzyl; or a pharmaceutically acceptable salt thereof, which are useful in the treatment of a disease state in which an en- hancement of TxA2 synthesis exerts a pathogenic effect.

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