N-imidazolyl derivatives of substituted tetrahydrocarbazole...

Details N-imidazolyl derivatives of substituted tetrahydrocarbazole... N-imidazolyl derivatives of substituted tetrahydrocarbazole...

C - Chemistry, Metallurgy

07

D

C07D 403/10 (2006.01) A61K 31/415 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2059741

ABSTRACT The invention provides new N-imidazolyl derivatives of substituted tetrahydrocarbazoles and cyclopent[b]indoles of general formula (I) Image (I) wherein n is 1 or 2; p is an integer of 1 to 4; A is a straight or branched C1-C4 alkylene chain; B is a direct linkage, a straight or branched, unsaturated or saturated C1-C4 alkylene chain: Q is a direct linkage or a straight or branched C1-C4 alkylene chain; each of R1 and R2 independently is hydrogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkylthio, C1-C4 alkylsulfonyl, halogen or trihalomethyl; each of R3 and R5, independently is hydrogen or C1-C4 alkyl; R4 is -OR6 or -N(R6,R7) group, wherein each of R6 and R7 in- dependently is hydrogen, C1-C4 alkyl, phenyl or benzyl; or a pharmaceutically acceptable salt thereof, which are useful in the treatment of a disease state in which an enhancement of TxA2 synthesis exerts a pathogenic effect.

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