C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 233/54 (2006.01) A61K 31/415 (2006.01) C07D 233/68 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01)
Patent
CA 2270478
The invention concerns compounds of formula (I) in which R1 and R'1 represent hydrogen, halogen or (C1-C4) alkyl, R2 represents a piperidin-1-yl group, 1, 2, 3, 6-tetrahydropyridin-1-yl optionally substituted, hexahydro-1H-azepin-1- yl, heptahydroazocin-1-yl, octahydro-1H-azonin-1-yl, (a) (A-B = -CONR", m = 1 to 2 and p = 1 to 2), (b) (Q = carbon or nitrogen, D = (C1-C4) alkyl or - CH2CF3, and r = 1 to 3, R3 represents (C1-C5) alkyl, -COR5 [R5 being (C1-C4) alkyl, -(CH2)nOCH3, -CH2O(C2H4O)nCH3, -(CH2)nCF3, -(CH2)nOH (n = 1 to 4)], - SO2R6, -CONHR6, -SO2N(R6)2 (R6 being (C1-C4) alkyl), R4 represents hydrogen or halogen and A represents phenyl or heterocycle optionally substituted or cyclo (C5-C8) alkyl. The invention is applicable in therapeutics.
Composés de formule (I) dans laquelle R¿1? et R'¿1? représentent hydrogène, halogène ou (C¿1?-C¿4?)alkyle, R¿2? représente un groupe pipéridin-1-yle, 1,2,3,6-tétrahydropyridin-1-yle éventuellement substitués, hexahydro-1H-azépin-1-yle, heptahydroazocin-1-yle, octahydro-1H-azonin-1-yle, (a) (A-B = -CONR", m = 1 à 2 et p = 1 à 2), (b) (Q = carbone ou azote, D = (C¿1?-C¿4?)alkyle ou -CH¿2?CF¿3?, et r = 1 à 3), R¿3? représente (C¿1?-C¿5?)alkyle, -COR¿5? [R¿5? étant (C¿1?-C¿4?) alkyle, -(CH¿2?)¿n?OCH¿3?, -CH¿2?O(C¿2?H¿4?O)¿n?CH¿3?, -(CH¿2?)¿n?CF¿3?, -(CH¿2?)¿n?OH (n égal 1 à 4)], -SO¿2?R¿6?, -CONHR¿6?, -SO¿2?N(R¿6?)¿2? (R¿6? étant (C¿1?-C¿4?) alkyle), R¿4? représente hydrogène ou halogène et A représente phényle ou hétérocycle éventuellement substitués ou cyclo(C¿5?-C¿8?)alkyle. Application en thérapeutique.
Altenburger Jean-Michel
Galtier Daniel
Lassalle Gilbert
Martin Valerie
Kirby Eades Gale Baker
Synthelabo
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