N-methanesulfonic acid derivatives of 3-0- demethylistamycin...

Details N-methanesulfonic acid derivatives of 3-0- demethylistamycin... N-methanesulfonic acid derivatives of 3-0- demethylistamycin...

C - Chemistry, Metallurgy

07

H

260/357.5

C07H 15/22 (2006.01) C07H 15/224 (2006.01)

Patent

CA 1188308

N-Methanesulfonic acid derivatives of 3-0- demethylistamycin B and production thereof ABSTRACT OF THE DISCLOSURE As new semi-synthetic antibiotic derivative are provided N-methanesulfonic acid derivatives of 3-0- demethylistamycin B which are less toxic than the parent 3-0-demethylistamycin B and retain usefully high anti- bacterial activity of the parent antibiotic. The new derivatives are produced by a method of N-sulfomethylation where 3-0-demethylistamycin B is reacted with an aldehyde such as paraformaldehyde and sulfurous acid or sulfite reagent.

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