C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 333/70 (2006.01) A61K 31/34 (2006.01) A61K 31/38 (2006.01) A61K 31/40 (2006.01) A61P 35/00 (2006.01) C07D 209/42 (2006.01) C07D 307/85 (2006.01) C07D 307/86 (2006.01)
Patent
CA 2513401
Objects of the present invention are new mono-acylated o-phenylendiamines derivatives of formula (I), wherein X represents N, S or O; R represents CH3- (O-CH2CH2)n- or C1-C6-alkyl, which alkyl group is monosubstituted with -CO2H, - OH, R1R2N-, pyridin-2-yl, pyrrolidin-1-yl, piperidino or morpholino; R1, R2 independently from each other denote C1-C6 alkyl; n is 1, 2, 3 or 4; and pharmaceutically acceptable salts thereof. The present invention also encompasses pharmaceutically acceptable salts or prodrugs of the compounds of formula I as well as the use of these compounds to produce medicaments.
L'invention a trait à de nouveaux dérivés de o-phénylènediamines monoacylées représentés par la formule (I), dans laquelle X représente N, S ou O, R représente CH¿3?-(O-CH¿2?CH¿2?)n- ou alkyle en C¿1?-C¿6?, le groupe alkyle étant monosubstitué par -CO¿2?H, -OH, R?1¿R?2¿N-, pyridin-2-yl, pyrrolidin-1-yl, pipéridino ou morpholino, R?1¿ et R?2¿ représentent chacun indépendamment alkyle en C¿1?-C¿6?, n égale 1, 2, 3 ou 4 ; et à des sels pharmaceutiquement acceptables de ces dérivés. L'invention concerne aussi des sels ou des promédicaments pharmaceutiquement acceptables des composés représentés par la formule I, ainsi que l'utilisation de ces composés pour produire des médicaments.
Fertig Georg
Herting Frank
Kubbies Manfred
Limberg Anja
Reiff Ulrike
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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