N,n'-bis(2-(3-substituted-4-hydroxyphenyl)-ethyl or...

Details N,n'-bis(2-(3-substituted-4-hydroxyphenyl)-ethyl or... N,n'-bis(2-(3-substituted-4-hydroxyphenyl)-ethyl or...

C - Chemistry, Metallurgy

07

C

260/541, 260/546

C07C 229/38 (2006.01) C07C 275/24 (2006.01) C07C 275/40 (2006.01)

Patent

CA 1044699

ABSTRACT OF THE DISCLOSURE Polymethylenediamines are disclosed of the formula: Image in which n is a positive whole integer of from 4 to 8; Y is NH2, NHCHO, NHCOCH3, NHCONH2, NHSO2R, NHCO2R, NHCONHR, NHSO2NH2, NHSO2N(CH3)2, CH2OH, CH2NH2, CH2NHSO2R, CH2NHCONH2 or CH2SO2R; and R is lower alkyl of from 1 to 5 carbon atoms, straight or branched chain. The compounds have .beta.-adrenergic stimulant activity particularly as selected bronchodilators and are prepared generally by condensation of an N-benzyl- phenethlamine with a polymethylene dihalide or by reaction of an .alpha.-bromoacetophenone with an N,N'-dibenzyl-polymethylene- diamine, with further operations depending on the nature of the 3-substituent, and subsequently hydrogenating catalytically with for example palladium-on-carbon.

143419

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