N,n'-bis(2-hydroxybenzyl)ethylenediamine-n,n'-diacetic acid...

Details N,n'-bis(2-hydroxybenzyl)ethylenediamine-n,n'-diacetic acid... N,n'-bis(2-hydroxybenzyl)ethylenediamine-n,n'-diacetic acid...

C - Chemistry, Metallurgy

07

C

C07C 229/16 (2006.01) A61K 31/22 (2006.01) A61K 31/335 (2006.01) A61K 31/535 (2006.01) C07C 235/06 (2006.01) C07D 295/185 (2006.01) C07D 317/40 (2006.01)

Patent

CA 2179203

[N,N'-bis(2-hydroxybenzyl)ethylenediamine N,N'-diacetic acid] derivatives of formula (I) in which R represents -(CO)-R1, -O-(CO)-R2, -O-(CO)-O-R3 or (a) wherein R1 is -NR4R5 or (III); whereby R4 and R5 are independent of each other C1-C3 alkyl or C3-C7 cycloalkyl or form together the group -(CH2)n-, n is an integer from 3 to 6; R2 is C1-C6 alkyl, unsubstituted phenyl or phenyl substituted by one to four substituents selected from the group consisting of halogen and hydroxy; R3 is C1-C6 alkyl or C3-C7 cycloalkyl; R4 is C1-C3 alkyl; and salts thereof form chelate-type metal complexes with trivalent metal ions, especially iron (III), and can be used, for example, for the treatment of pathological conditions in warm-blooded animals that are associated with an excess of trivalent metal ions in the body.

Des dérives d'[acide diacétique N,N'-bis(2-hydroxybenzyl)éthylènediamine-N,N'] de formule (I) dans laquelle R représente -(CO)-R¿1?, -O-(CO)-R¿2?, -O-(CO)-O-R¿3? ou bien (a) où R¿1? est -NR¿4?R¿5? ou bien (III); où R¿4? et R¿5? sont indépendamment l'un de l'autre alkyle C¿1?-C¿3? ou bien cycloalkyle C¿3?-C¿7? ou encore forment ensemble le groupe -(CH¿2?)¿n?-, n est un entier compris entre 3 et 6; R¿2? est alkyle C¿1?-C¿6?, phényle non substitué ou phényle substitué par un à quatre substituants choisis dans le groupe composé d'halogène et d'hydroxy; R¿3? est alkyle C¿1?-C¿6? ou bien cycloalkyle C¿3?-C¿7?; R¿4? est alkyle C¿1?-C¿3?; et leurs sels forment des complexes métalliques de type chélate avec des ions métalliques trivalents, notamment du fer (III), et peuvent être utilisés par exemple pour le traitement d'états pathologiques, chez des animaux homéothermes, qui sont associés à un excès d'ions métalliques trivalents dans le corps.

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