N,n'-bis(alkoxyalkyl)-pyridine-2,4-dicarboxylic acid...

Details N,n'-bis(alkoxyalkyl)-pyridine-2,4-dicarboxylic acid... N,n'-bis(alkoxyalkyl)-pyridine-2,4-dicarboxylic acid...

C - Chemistry, Metallurgy

07

D

167/229, 260/296

C07D 213/81 (2006.01) A61K 31/44 (2006.01) C07D 213/82 (2006.01)

Patent

CA 2021529

N,N'-Bis(alkoxyalkyl)-pyridine-2,4-dicarboxylic acid diamides, preparation and their use The invention relates to N,N'-bis(alkoxyalkyl)-pyridine- 2,4-dicarboxylic acid diamides of the formula I Image (I) wherein R1, R2, n, R1', R2' and n' have the meanings given. The compounds inhibit proline hydroxylase and lysine hydroxylase and are suitable as fibrosuppressants and immunosuppressants.

N,N'-Bis(alcoxyalkyl)pyridine-2,4-dicarboxylamides; méthode de préparation et applications. L'invention concerne les N,N'-bis(alcoxyalkyl)pyridine-2,4-dicarboxylamides de formule I Image (I), dans laquelle R1, R2, n, R1', R2' et n' ont la signification spécifiée. Ces composés sont des inhibiteurs de la proline- hydroxylase et de la lysine-hydroxylase; ils sont utiles comme fibrosuppresseurs et immunosuppresseurs.

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