N,n'-[bis(n-cyanoguanyl)] crystamine derivatives

C - Chemistry – Metallurgy – 07 – D

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260/540.3

C07D 233/54 (2006.01) C07C 323/44 (2006.01)

Patent

CA 1118445

III. Abstract: Novel compounds of the formula Image IV wherein each R1 is the same and is a straight or branched chain alkynyl group containing from 3 to 9 carbon atoms, inclusive, which are useful inter- mediates in the preparation of anti-ulcer agents, are prepared by reacting cystamine (VI) with an N-cyano-N'-alkynyl-S-methylisothiourea of the formula Image VII in which R1 is as defined above.

329501

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