N,n'-bis(quinolin-4-yl)-diamine derivatives, their...

Details N,n'-bis(quinolin-4-yl)-diamine derivatives, their... N,n'-bis(quinolin-4-yl)-diamine derivatives, their...

C - Chemistry, Metallurgy

07

D

C07D 215/46 (2006.01) A61K 31/47 (2006.01) C07D 215/44 (2006.01)

Patent

CA 2192203

Disclosed are N,N'-bis(quinolin-4-yl)-diamine derivatives of general formula (I) wherein R1 signifies halogen or trifluoromethyl, R2 signifies hydrogen or halogen, A signifies cyclohexane-1,3-diyl, 2-methyl-cyclohexane-1,3-diyl, cyclohexane-1,4-diyl, dicyclohexylmethane-4,4'-diyl, cyclopentane-1,3-diyl, phenylene-1,4, phenylene-1,3, phenylene-1,2, ethene-1,2-diyl or ethyne-1,2- diyl and n and m can be the same or different and signify 0, 1 or 2, as well as their pharmaceutically acceptable salts. These products are useful as agents for preventing malaria and for treating it, especially where the pathogens are resistant to chloroquine.

Dérivés N,N'-bis(quinolin-4-yle)-diamine de la formule générale (I) ainsi que leurs sels acceptables sur le plan pharmacologique. Dans cette formule, R?1¿ représente halogène ou trifluorométhyle, R?2¿ représente hydrogène ou halogène, A représente cyclohexane-1,3-diyle, 2-méthyl-cyclohexane-1,3-diyle, cyclohexane-1,4-diyle, dicyclohexylméthane-4,4'-diyle, cyclopentane-1,3-diyle, phénylène-1,4, phénylène-1,3, phénylène-1,2, éthène-1,2-diyle ou éthyne-1,2-diyle, et n et m peuvent être semblables ou différents et valent 0, 1 ou 2. Ces produits sont utiles en tant qu'agents destinés à la prévention ou au traitement de la malaria, notamment dans les cas où les agents pathogènes sont résistants à la chloroquine.

Affiliated with

Also associated with

Rating

N,n'-bis(quinolin-4-yl)-diamine derivatives, their... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with N,n'-bis(quinolin-4-yl)-diamine derivatives, their..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and N,n'-bis(quinolin-4-yl)-diamine derivatives, their... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1866142