N,n'-bis(sulfonyl)hydrazines useful as antineoplastic agents

Details N,n'-bis(sulfonyl)hydrazines useful as antineoplastic agents N,n'-bis(sulfonyl)hydrazines useful as antineoplastic agents

C - Chemistry, Metallurgy

07

C

C07C 311/53 (2006.01) A61K 31/325 (2006.01) A61K 31/661 (2006.01) A61P 35/00 (2006.01) C07F 9/09 (2006.01) C07F 9/12 (2006.01)

Patent

CA 2308315

The present invention relates to a compound of formula (I) wherein R1 and R2 are selected from lower alkyl groups having 1-6 carbon atoms, substituted or unsubstituted aryl groups, and unsaturated alkyl groups having 1-6 carbon atoms; R3 is a substituted or unsubstituted lower alkyl group having 1-6 carbons; and R4 is selected from substituted or unsubstituted lower alkyl groups having 1-6 carbon atoms, substituted or unsubstituted aryl groups, and unsaturated alkyl groups having 1-6 carbon atoms. The present invention also relates to a pharmaceutical composition comprising the above compound, as well as a method of treating tumor cells with the compound.

La présente invention porte sur un composé de la formule (I) dans laquelle R<1> et R<2> sont sélectionnés parmi des groupes alkyle possédant de 1 à 6 atomes de carbone, des groupes aryle substitués ou non substitués et des groupes alkyle insaturés possédant de 1 à 6 atomes de carbone; R<3> est un groupe alkyle inférieur substitué ou non substitué possédant de 1 à 6 atomes de carbone; et R<4> est sélectionné parmi des groupes alkyle inférieur substitués ou non substitués possédant de 1 à 6 atomes de carbone, des groupes aryle substitués ou non substitués et des groupes alkyle insaturés possédant de 1 à 6 atomes de carbone. La présente invention porte également sur une composition pharmaceutique comprenant le composé précité, ainsi que sur un procédé de traitement des cellules tumorales à l'aide de ce composé.

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