A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/21 (2006.01) A61K 31/24 (2006.01) A61K 31/405 (2006.01) C07C 69/608 (2006.01) C07C 69/612 (2006.01) C07C 69/616 (2006.01) C07C 69/618 (2006.01) C07C 69/73 (2006.01) C07C 229/32 (2006.01) C07C 229/34 (2006.01) C07D 209/12 (2006.01) C07D 209/14 (2006.01) C07D 209/22 (2006.01)
Patent
CA 2309135
The compound, ((3-(2-amino-1,2-dioxoethyl)-1-((1,1'-biphenyl)-3-ylmethyl)-2- methyl-1H-indol-4-yl)oxy)acetic acid N,N-diethylglycolamido ester, is disclosed together with its use as a highly bioavailable indole compound for inhibiting sPLA2 mediated release of fatty acids for treatment of conditions such as septic shock.
L'invention concerne le composé d'ester de N,N-diéthylglycolamido d'acide ((3-(2-amino-1,2-dioxoéthyl)-1-((1,1'-biphényl)-3-ylméthyl)-2-méthyl-1H-indol-4-yl) oxy)acétique, ainsi que son utilisation en tant que composé indolique présentant une biodisponibilité élevée et servant à inhiber la libération provoquée par l'intermédiaire de sPLA¿2? d'acides gras afin de traiter des états tels que le choc septique.
Denney Michael Lyle
Morin John Michael Jr.
Sall Daniel Jon
Sawyer Jason Scott
Eli Lilly And Company
Gowling Lafleur Henderson Llp
LandOfFree
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