N,n-dioxides of bis-basic cyclic ketones

Details N,n-dioxides of bis-basic cyclic ketones N,n-dioxides of bis-basic cyclic ketones

C - Chemistry, Metallurgy

07

D

260/278.1, 260/5

C07D 311/86 (2006.01) C07D 295/10 (2006.01) C07D 295/108 (2006.01) C07D 295/22 (2006.01) C07D 295/24 (2006.01) C07D 311/82 (2006.01)

Patent

CA 1042442

ABSTRACT OF THE DISCLOSURE A process for the preparation of a N,N-dioxide of a bis-basic cyclic ketone having the formula Image wherein Z is oxygen or H2; R1 is carbon; R2 is a sigma bond; R3 is methylidene; A is a straight or branched alkylene chain having from 2 to 4 carbon atoms; R4 and R5 are lower alkyl having from 1 to 3 carbon atoms and when taken together with the nitrogen atom to which it is attached is piperidino; R? is selected from the group consisting of hydrogen and Image with the proviso that one and only one such R? group is hydrogen; R1, Z and R3 taken together form the group Image when each R? is hydrogen and R2 is a sigma bond; or a pharmaceutically acceptable acid addition salt thereof. These compounds are useful for the prevention and inhibition of virus infections.

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