C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 405/00 (2006.01) A61K 31/16 (2006.01) A61K 31/36 (2006.01) A61K 31/38 (2006.01) A61K 31/425 (2006.01) A61K 31/495 (2006.01) C07C 233/00 (2006.01) C07D 277/30 (2006.01) C07D 317/44 (2006.01) C07D 317/60 (2006.01) C07D 333/20 (2006.01) C07D 333/24 (2006.01) C07D 333/36 (2006.01) C07D 405/14 (2006.01) C07D 409/00 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2328990
A method for the inhibition of the binding of .alpha.4.beta.1 integrin to its receptors, for example VCAM-1 (vascular cell adhesion molecule-1) and fibronectin; compounds that inhibit this binding; pharmaceutically active compositions comprising such compounds; and the use of such compounds either as above, or in formulations for the control or prevention of diseases states in which .alpha.4.beta.1 is involved.
L'invention concerne une méthode permettant d'inhiber la fixation d'une intégrine .alpha.¿4?.beta.¿1? à ses récepteurs, par exemple la VCAM-1 (molécule-1 d'adhésion cellulaire vasculaire) et la fibronectine. L'invention concerne également des composés destinés à inhiber cette fixation, des compositions pharmaceutiques actives renfermant ces composés, et l'utilisation de ces composés dans le but susmentionné ou dans des formulations visant à prévenir ou à traiter des troubles liés à la .alpha.¿4?.beta.¿1?.
Biediger Ronald J.
Grabbe Vanessa O.
Kassir Jamal M.
Kogan Timothy P.
Lin Shuqun
Encysive Pharmaceuticals Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Texas Biotechnology Corporation
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