N,n'-disubstituted guanidines and their use as excitatory...

Details N,n'-disubstituted guanidines and their use as excitatory... N,n'-disubstituted guanidines and their use as excitatory...

A - Human Necessities

61

K

A61K 31/155 (2006.01) A61K 31/365 (2006.01) A61K 31/47 (2006.01)

Patent

CA 2117592

N,N'-disubstituted guanidines exhibiting a high binding affinity to phencyclidine (PCP) receptors are disclosed. These N,N'-disubstituted guanidine derivatives act as non-competitive inhibitors of glutamate induced responses generated via the NMDA receptor by acting as blockers for the ion channel of the NMDA receptor-ion channel complex. These compounds thus exert a neuroprotective property and are useful in the therapeutic treatment of neuronal loss in hypoxia, hypoglycemia, brain or spinal cord ischemia, brain or spinal cord trauma, as well as being useful for the treatment of epilepsy, Alzheimer's disease, Amy- otrophic Lateral Sclerosis, Huntington's disease, Down's Syndrome, Korsakoff's disease and other neurodegenerative disorders.

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