N, n'-substituted-1,3-diamino-2-hydroxypropane derivatives

Details N, n'-substituted-1,3-diamino-2-hydroxypropane derivatives N, n'-substituted-1,3-diamino-2-hydroxypropane derivatives

C - Chemistry, Metallurgy

07

C

C07C 215/28 (2006.01) A61K 31/13 (2006.01) C07C 233/36 (2006.01) C07C 233/40 (2006.01) C07C 233/58 (2006.01) C07C 233/78 (2006.01) C07C 235/20 (2006.01) C07C 235/50 (2006.01) C07C 235/74 (2006.01) C07C 237/04 (2006.01) C07C 237/06 (2006.01) C07C 237/08 (2006.01) C07C 237/22 (2006.01) C07C 237/42 (2006.01) C07C 251/38 (2006.01) C07C 255/58 (2006.01) C07C 271/28 (2006.01) C07C 271/44 (2006.01) C07C 311/08 (2006.01) C07C 311/16 (2006.01) C07C 311/17 (2006.01) C07C 311/18 (2006.01) C07C 311/19 (2006.01) C07C 31

Patent

CA 2466284

Disclosed are compounds of the formula (I), wherein the variables RN, RC, R1, R25, R2, and R3 are as defined herein. These compounds have activity as inhibitors of betasecretase and are therefore useful in treating a variety of discorders such as Alzheimer's Disease.

L'invention concerne des composés de formule (I) dans laquelle les variables RN, RC, R¿1?, R¿25?, R¿2? et R¿3? ont la signification mentionnée dans la description. Ces composés ont une activité d'inhibiteurs de bétasecrétase et s'utilisent de ce fait dans le traitement d'une variété de troubles tels que la maladie d'Alzheimer.

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