N-(n-succinyl-l-leucyl) agmatine, related compounds and use...

Details N-(n-succinyl-l-leucyl) agmatine, related compounds and use... N-(n-succinyl-l-leucyl) agmatine, related compounds and use...

C - Chemistry, Metallurgy

07

C

260/470, 260/525

C07C 271/12 (2006.01) C07C 271/20 (2006.01) C07C 279/12 (2006.01) C07C 279/14 (2006.01) C07C 279/36 (2006.01)

Patent

CA 2002140

TITLE OF THE INVENTION: N-(N-SUCCINYL-L-LEUCYL)AGMATINE, RELATED COMPOUNDS AND USE IN PHARMACOLOGY ABSTRACT OF THE DISCLOSURE Compounds having the formula: Image (1) wherein R1 is -NH(C=O)OR5, -NH(C=NH)NH2 or -NH(C=N-NO2)HN2; R2 is hydrogen, C1-8alkyl or C6-8aryl; n is 2 to 6; and R5 is hydrogen, C1-8alkyl, C6-8aryl, or C7-8alkaryl; are disclosed in addition to methods to employ such compounds to induce migration of endothelial cells into denuded areas of vessel lining and to treat malignant hypercalcemia.

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