N-naphthoylglycines as aldose reductase inhibitors

Details N-naphthoylglycines as aldose reductase inhibitors N-naphthoylglycines as aldose reductase inhibitors

C - Chemistry, Metallurgy

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C

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C07C 237/48 (2006.01) A61K 31/195 (2006.01) C07C 43/225 (2006.01) C07C 43/23 (2006.01) C07C 65/24 (2006.01) C07C 235/66 (2006.01) C07C 237/22 (2006.01) C07C 271/64 (2006.01) C07C 327/48 (2006.01)

Patent

CA 1307537

ABSTRACT OF THE DISCLOSURE Disclosed herein are N-naphthoylglycines and methods of their preparation. The N-naphthoyl- glycines are novel aldose reductase inhibitors useful for the treatment or prevention of diabetic complications. The N-naphthoylglycines have the following formula Image (I) wherein R is halogen or lower alkoxy containing 1 to 5 carbon atoms, trifluoroethoxy, phenoxy or phenyl- methoxy; X is =0 or =S; Y is-OH, -NH2 or -NHCO2CH2CH3.

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