N,o-carboxymethylchitosan for prevention of surgical adhesions

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/722 (2006.01) A61L 17/00 (2006.01) A61L 26/00 (2006.01) A61L 31/04 (2006.01) A61P 41/00 (2006.01)

Patent

CA 2220505

The invention relates to a method of treating patients to minimize post- surgical adhesions and a kit useful in the method of the invention. The method is based on the finding that N,O-carboxymethylchitosan (NOCC) has advantageous properties as a wound healing lavage and coating. A NOCC solution is particularly effective as a post- surgical lavage and when used in conjunction with a NOCC gel coating, wound healing rate is unchanged while the number and severity of adhesions is greatly reduced.

L'invention concerne un procédé de traitement de patients afin de limiter au maximum les adhésions post-chirurgicales, ainsi qu'un nécessaire de mise en application dudit procédé. Ce procédé se base sur la découverte des propriétés avantageuses du N,O-carboxyméthylchitosan (NOCC) en tant qu'agent de cicatrisation, de lavage et de revêtement de lésions. Une solution de NOCC est particulièrement efficace en tant que lavage post-chirurgical et quand on l'utilise en combinaison avec une couche de gel à base de NOCC, la vitesse de cicatrisation des lésions reste inchangée, tandis que le nombre et la gravité des adhésions diminuent fortement.

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