C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/271, 260/276
C07D 401/00 (2006.01) C07D 213/89 (2006.01) C07D 401/04 (2006.01) C07D 471/04 (2006.01) C07D 491/04 (2006.01) C07D 491/048 (2006.01)
Patent
CA 1215053
- 1 - N-oxide compounds, processes for their manufacture and pharmaceutical compositions containing them Abstract The present invention relates to novel N-oxide compounds that have cardiovascular properties, espec- ially antihypertensive activity, and that correspond to the formula Image (I) in which Py represents an unsubstituted or substituted N-oxidopyridyl radical, R1 represents hydrogen or unsubstituted or substituted lower alkyl, one of the radicals R2 and R3 represents lower alkyl and the other represents hydrogen; lower alkyl; lower alkyl contain- ing free, etherified or esterified hydroxy, oxo, functionally modified carboxy or free or substituted amino or imino; functionally modified carboxy; or free or substituted amino, it being possible for an amino group R2 or R3 to be bonded to a lower alkyl radical R1 or, if R2 or R3 represents, for example, hydroxy-lower alkyl, for this hydroxy-lower alkyl, together with the adjacent acyl radical Ac1 or Ac2, to form a 2-oxa-1-oxo- lower alkylene radical, the carbonyl group of which is bonded to the 3- or 5-ring carbon atom of the 1,4- dihydropyridine ring, and each of the groups Ac1 and Ac2 - 2 - represents, independently of the other, the acyl radical of an acid, and salts of compounds of the formula I having salt-forming groups, processes for the manufacture of these compounds, the use of these compounds and their salts, and pharmaceutical preparations which contain these compounds and salts, as antihypertensive agents and coronary dilators for the treatment of cardiovascular conditions, such as hypertonic, vascular constrictions, Angina pectoris and cardiac insufficiency.
418753
Kuhnis Hans
Zimmermann Markus
Fetherstonhaugh & Co.
Novartis Ag
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