C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 229/28 (2006.01) A61K 31/195 (2006.01) A61K 31/66 (2006.01) C07F 9/547 (2006.01) C07F 9/6584 (2006.01)
Patent
CA 2504496
This invention relates to compounds which are N-oxides and derivatives thereof, as well as their use to treat HIF related diseases. These compounds have the general formula set out below and are used to treat a variety of diseases associated with HIF: formula (I) wherein R is an alkyl, aryl, arakyl or derivatives thereof such as CH3OCH2CH2- , CH3 CH2OCH2CH2- , C6H5OCH2CH2- , C6H5CH2- , CH3 (CH2)3OCH2CH2Cl; or any one of the formula (II), formula (III) and formula (IV).
La présente invention a trait à des composés qui sont des N-oxydes et leurs dérivés, ainsi qu'à leur utilisation pour le traitement de maladies liées au facteur inductible d'hypoxie. Ces composés sont de formule générale (I), dans laquelle : R est un alkyle, aryle, aralkyle ou des dérivés de ceux-ci tels que CH¿3?OCH¿2?CH¿2?-, CH¿3? CH¿2?OCH¿2?CH¿2?-, C¿6?H¿5?OCH¿2?CH¿2?-, C¿6?H¿5?CH¿2?-, CH¿3? (CH2)¿3?OCH¿2?CH¿2?Cl ; ou une quelconque parmi les formules (II), (III) et (IV). Lesdits composés sont utiles dans le traitement de diverses maladies liées au facteur inductible d'hypoxie.
Kirkpatrick Lynn
Powis Garth
Welsh Sarah J.
Arizona Board Of Regents Acting On Behalf Of The University Of Arizona
Borden Ladner Gervais Llp
Prolx Pharmaceuticals Corporation
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